ﾎﾟｰﾀﾌﾞﾙ水分蒸散計 - キーストンサイエンティフィックLOGO

ポータブル水分蒸散計 VapoMeter® バポメーター： TEWL(経皮水分蒸散量/経表皮水分喪失量）、フランツ型拡散セル/経皮吸収試験器からの蒸散量測定、皮膚バリア機能、 ... ポータブル水分蒸散計VapoMeter　 主な特徴     ,http://gdata.youtube.com/feeds/api/videos/Onu6J8O6mV8,,{"playerWidth":"425","useCustom":false,"autoPlay":false,"autoLoop":false,"autoNext":false,"quality":"default","qualityName":"自動","coverImage":""}   より強化された基本性能 測定時間は7-12秒。

皮膚等をブロックすることなく自然なTEWL(水分蒸散量)を測定します。

新型センサー/チャンバーの採用で基本性能が向上、より外気の影響を受けにくい構造です。

また繰り返し測定や換気時間も改善しています。

１）化粧品産業用研究機器　２）国内技適済みワイヤレスモデム内蔵  表示画面部分を大幅に改善  新たにカラーLEDを採用。

通信状態、アダプターの種類、チャンバー内の温湿度、直近５回の測定履歴、グラフ、次回校正時期、電池残量等を確認できます。

また日本語、英語表示からお選びいただけます。

環境温度を独立したセンサーで測定（オプション） 本体チャンバー内の湿温度とは別に測定をする部屋の環境を捉えるセンサーを用意しました。

今回から採用されたBluetoothによる通信でこの環境データと測定結果を同期してパソコン側に記録されます。

従来からのアダプター等は全て互換 標準添付の小型アダプターで唇、頭皮のTEWL(水分蒸散量)も。

また膜透過・経皮吸収試験用Franz-Cell専用アダプターを用意（17mm、15mm、11.28mm、9mm）もオプションで用意しています。

アプリケーション TEWL、皮膚バリア機能、透過試験 肌荒れの評価 スキンケア、スキントリートメント、栄養効果 幼児のSSWL、おむつの評価 動物皮膚、トリートメント、栄養効果 In-vitro試験 フランツセルにおける試験前・後の膜の確認、シールドのチェック 植物（光合成）からの蒸散の評価・測定  測定の仕組み 経皮蒸散量測定の原理 本体の開口部から内蔵センサーまでの構造は、ほぼ密閉された円筒の形をしています。

測定は本体のスイッチを押し、電子音の合図で測定部位に開口部を押し当てると約７－12秒間で測定が行われます。

内部のセンサーがこの間のＴＥＷＬ値を計算し、外気の湿度と相対温度も合わせて表示します。

換気時間の調整中はスタートボタンにロックがかかり、換気終了と同時に再度スタートが可能になります。

  従来型経皮蒸散量測定機器との比較 上のグラフは古くから使用されている開放型蒸散計との比較です。

機器が理論上の計算でどれだけ正確かを実験するためメンブレン（水蒸気を通す膜）で覆われた皮膚モデルからの蒸散を測定します。

ＶａｐｏＭｅｔｅｒでの蒸散量測定値と計算上の蒸散値では220ｇ/ｍ2ｈまで高い相関がれあられました。

一方の開放型蒸散計では120ｇ/ｍ2付近から著しい相違が見られます。

消耗品・アクセサリー 品番：SWL2050　　水分蒸散計用ネイルアダプター（10個入り） ネイル表面、唇、頭皮その他小領域用。

本体測定モードはネイル（nlA）を使用。

品番：SWL2040-17　　17mm用フランツセルアダプター（10個入り） オリフィス17mm、透過面積が2.3cm2のフランツセル用。

本体測定モードは標準（SdA）を使用。

品番：SWL2040-15　15mm用フランツセルアダプター（10個入り） オリフィス15mm、透過面積が1.7cm2のフランツセル用。

本体測定モードは標準（ｓdA）を使用。

品番：SWL2040-11.28　11.28mm用フランツセルアダプター（10個入り） オリフィス11.28mm、透過面積が1.0cm2のフランツセル用。

本体測定モードは標準（SdA）を使用。

品番：SWL2040-09　9mm用フランツセルアダプター（10個入り） オリフィス9mm、透過面積が0.64cm2のフランツセル用。

本体測定モードはネイル（nlA）を使用。

文献リスト TEWL、皮膚バリア機能、透過試験 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肌荒れ SkinbarrierimpairmentcorrelateswithcutaneousStaphylococcusaureuscolonizationandsensitizationtoskin-associatedmicrobialantigensinadultpatientswithatopicdermatitisJinnestålC.L.,BelfrageE.,BäckO.,SchmidtchenA.andSonessonA.IntJDermatol,epubJul24,2013. TRPA1controlsinflammationandpruritogenresponsesinallergiccontactdermatitisLiuB.,EscaleraJ.,BalakrishnaS.,FanL.,CaceresA.I.,RobinsonE.,SuiA.,McKayM.C.,McAlexanderM.A.,HerrickC.A.andJordtS.E.FASEBJ,Sep;27(9):3549-63,2013. SkincharacteristicsofChinesemenandtheirbeardremovalhabitsWuY.,KonduruR.andDengD.BrJDermatol,Mar;166(IssueSuplements1):17-21,2012. AnimprovedmethodformeasurementofchangeinskinroughnesscausedbycleansingproductsundermildapplicationconditionsLeeE.,AnS.,ImM.-S.,KimH.K.andLeeT.R.SkinResTechnol,Aug;17(3):320-325,2011. Frequencyandseverityofdiaperdermatitiswithuseoftraditionalchineseclothdiapers:Observationsin3-to9-month-oldchildrenLiu,N.,Wang,X.andOdio,M.PediatricDermatology,Jul/Aug;28(4):380–386,2011. TheuseofameasureofacuteirritationtopredicttheoutcomeofrepeatedusageofhandsoapproductsWilliamsC.,WilkinsonM.,McShaneP.,PenningtonD.,FernandezC.andPierceS.BrJDermatol,Jun;164(6):1311-1315,2011. Influenceoftumournecrosisfactor-αpolymorphism−308andatopyonirritantcontactdermatitisinhealthcareworkersDavisJ.A.,VisscherM.O.,WickettR.R.andHoathS.B.ContactDermatitis,Dec;63(6):320–332,2010. SpontaneousitchintheabsenceofhyperalgesiainamousehindpawdryskinmodelAkiyamaT.,CarstensM.I.andCarstensE.NeuroscienceLetters,Oct22;484(1),62-75,2010. Adouble-blind,randomizedstudytoassesstheeffectivenessofdifferentmoisturizersinpreventingdermatitisinducedbyhandwashingtosimulatehealthcareuseWilliamsC.,WilkinsonS.,McShaneP.,LewisJ.,PenningtonD.,PierceS.andFernandezC.BrJDermatol,May;162(5):1088–1092,2010. EffectsofglycerolonhumanskindamagedbyacutesodiumlaurylsulphatetreatmentAtrux-TallauN.,RomagnyC.,PadoisK.,DenisA.,HaftekM.,FalsonF.,PirotF.andMaibachH.I.ArchDermatolRes,302:435–441,2010. Microbiologicalefficacyandtolerabilityofanew,non-alcohol-basedhanddisinfectantAgtheN.,TerhoK.,KurvinenT.,RoutamaaM.,PeltonenR.,LaitinenK.andKanervaM.InfectControlHospEpidemiol.Jul;30(7):685-90,2009. RoleofTNF-polymorphism-308inirritantcontactdermatitisandneurosensoryresponseDavisJ.A.PhDThesis.Departmentofpharmaceuticalsciencesofthecollegeofpharmacy,UniversityofCincinnati,2009. ThealkalinepH-adaptedskinbarrierisdisruptedseverelybySLS-inducedirritationKimE.,KimS.,NamG.V.,LeeH.,MoonS.andChangI.IntJCosmetSci,31:4:263-269,2009. Skinbarrierdisruptionbysodiumlaurylsulfate-exposurealterstheexpressionsofinvolucrin,transglutaminase1,profilaggrin,andkallikreinsduringtherepairphaseinhumanskininvivoTörmäH.,LindbergM.andBerneB.JInvestDermatol,May;128(5):1212-9,2008. DifferentialcytokineexpressioninskinaftersingleandrepeatedirritationbysodiumlaurylsulphatedeJonghC.M.,LutterR.,VerberkM.M.andKezicS.ExpDermatol,16:1032-1040,2007. Arandomized,controlled,double-blindstudyoftheeffectofwearingcoatedpH5.5latexglovescomparedwithstandardpowder-freelatexglovesonskinpH,transepidermalwaterlossandskinirritationMirzaR.,MaaniN.,LiuC.,KimJ.andRehmusW.ContactDermatitis,Jul;55(1):20-5,2006. StratumcorneumcytokinesandskinirritationresponsetosodiumlaurylsulphatedeJonghC.M.,VerberkM.M.,WithagenC.E.T.,JacobsJ.J.L.,RustemeyerT.andKezicS.ContactDermatitis,Jun;54(6):325-33,2006. Skinreactionandrecovery:arepeatedsodiumlaurylsulphatepatchtestvs.a24-hpatchtestandtapestrippingKoopmanD.G.,KezicS.,VerberkM.M.BrJDermatol,Mar;150(3):493-9,2004. Abstracts Evaluationoflong-termperformanceutilizingahighabsorbencyadultincontinencebriefinalong-termcaresettinganditsimpactonoverallskinhealth.Kennedy-EvansK.L.,SalomonS.andBarbaK.InnovatingforContinence:TheEngineeringChallenge2011,Apr11-13,2011,Lincolnshire,Illinois. Theeffectofdifferentincontinence“gel-based”briefsonskinbarrierfunctionininstitutionalisedadults.SalomonS.,MilneC.T.,SaucierD.andBarbaK.InnovatingforContinence:TheEngineeringChallenge2011,Apr11-13,2011,Lincolnshire,Illinois. Theeffectofdifferentincontinencebriefsonskinbarrierfunctionininstitutionalizedadults.MilneC.T.,SaucierD.,SalomonS.andBarbaK.2010Wound,OstomyandContinenceNursingSocietyandWorldCouncilofEnterostomalTherapistsJointConference,Jun12-16,2010.   スキンケア、スキントリートメントの効果、栄養関連 Evaluationoftheefficacyandsafetyforatopicdryskinofamedicinalmoisturizinglotion(MentholatumAPSoftMedicinalMoistureLotion)preparedbyahigh-pressureemulsificationmethodOmiT.andOchiaiY.JCosmetDermatolSciAppl,3:145-150,2013. AnalysisofthetemporalchangeinbiophysicalparametersafterfractionallasertreatmentsusingreflectanceconfocalmicroscopyShinM.-K.,KimM.-J.,BaekJ.-H.,YooM.-A.,KohJ.-S.,LeeS.-J.andLeeM.-H.SkinResTechnol,19:e515–e520,2013. EffectofbathingonatopicdermatitisduringthesummerseasonKimH.,BanJ.,ParkM.-R.,KimD.-S.,KimH.-Y.,HanY.,AhnK.andKimJ.AsiaPacAllergy,2:269-274,2012. Influenceofapore-formingagentonswelling,networkparameters,andpermeabilityofpoly(ethyleneglycol)-crosslinkedpoly(methylvinylether-co-maleicacid)hydrogels:ApplicationintransdermaldeliverysystemsRajSinghT.R.,GarlandM.J.,MigalskaK.,SalvadorE.C.,ShaikhR.,McCarthyH.O.,WoolfsonD.A.andDonnellyR.F.JApplPolymSci,Aug;125(4):2680–2694,2012. Rheologicalcharacterizationofaxanthan-galactomannanhydrogelloadedwithlipophilicsubstancesKoopH.S.,Da-LozzoE.J.,deFreitasR.A.,FrancoC.R.,MitchellD.A.andSilveiraJ.L.JPharmSci,Jul;101(7):2457-2467,2012. EvaluationoftheclinicalefficacyoffractionalradiofrequencymicroneedletreatmentinacnescarsandlargefacialporesChoS.I.,ChungB.Y.,ChoiM.G.,BaekJ.H.,ChoH.J.,ParkC.W.,LeeC.H.andKimH.O.DermatolSurg,Jul;38(7Pt1):1017-24,2012. TheeffectofobesityonskindiseaseandepidermalpermeabilitybarrierstatusinchildrenNinoM.,FranzeseA.,RuggieroPerrinoN.andBalatoN.PediatrDermatol,Sop-Oct;29(5):567-70,2012. Fabricationofpseudo-ceramide-basedlipidmicroparticlesforrecoveryofskinbarrierfunctionKimD.-H.,ParkW.R.,KimJ.H.,ChoE.C.,AnE.J.,KimJ.-W.andOhS.G.ColloidsSurfBBiointerfaces,Jun;1(94):236-241,2012. SkincharacteristicsofChinesemenandtheirbeardremovalhabitsWuY.,KonduruR.andDengD.BrJDermatol,Mar;166(IssueSuplements1):17-21,2012. Differentialeffectsofdietarysupplementsonmetabolomicprofileofsmokersversusnon-smokersSpitaleR.C.,ChengM.Y.,ChunK.A.,GorellE.S.,MunozC.A.,KernD.G.,WoodS.M.,KnaggsH.E.,WulffJ.,BeebeK.D.andChangA.L.GenomeMed,Feb;4(2):14,2012. Evaluationofnutritionalstatusandskinconditionamongelderlyresidentsinalong-termcarehospitalIizakaS.,JiaoL.,SugamaJ.,MinematsuT.,ObaM.,MatsuoJ.,TabataK.,SugiyamaT.andSanadaH.JNutrHealthAging,Jan;16(1):107-111,2012. TranscutaneousDNAimmunizationfollowingwaxing-basedhairdepilationSloatB.R.,KiguchiK.,XiaoG.,DiGiovanniJ.,MauryW.andCuiZ.JControlRelease,Jan;157(1):94-102,2012. AnimprovedmethodformeasurementofchangeinskinroughnesscausedbycleansingproductsundermildapplicationconditionsLeeE.,AnS.,ImM.-S.,KimH.K.andLeeT.R.SkinResTechnol,Aug;17(3):320-325,2011. Beneficialeffectofdietaryepigallocatechin-3-gallateonskinviaenhancementofantioxidantcapacityinbothbloodandskinJeonH.Y.,KimJ.K.,SeoD.B.,ChoS.Y.andLeeS.J.SkinPharmacolPhysiol,23(6):283-289,2010. Influenceoftumournecrosisfactor-αpolymorphism−308andatopyonirritantcontactdermatitisinhealthcareworkersDavis,J.A.,Visscher,M.O.,WickettR.R.andHoath,S.B.ContactDermatitis,Dec;63(6):320–332,2010. Toleranceofbabycleansersininfants:ArandomizedcontrolledtrialDizonM.V.,GolzoteC.,EstanislaoR.,MathewN.andSarkarR.IndianPediatrics,Nov7;47(11):959-63,2010. Effectoforalintakeofceramide-containingaceticacidbacteriaonskinbarrierfunctionOdaT.,TachimotoH.,KishiM.andKagaT.andIchihashiM.Anti-AgingMedicine,7(5):50-54,2010. DevelopmentofsolarUVR-relatedpigmentationbeginsasearlyasthefirstsummeroflifeMackM.C.,TierneyN.K.,RuvoloE.Jr.,StamatasG.N.,MartinK.M.andKolliasN.JInvestDermatol,Sep;130(9):2335-2338,2010. 5-aminolevulinicacid-basedphotodynamicintensepulsedlighttherapyshowsbettereffectsinthetreatmentofskinphotoaginginasianskinYangG.,XiangL.H.andGoldM.H.JClinAesthetDermatol.,March;3(3):40-43,2010. Arandomized,controlledcomparativestudyofthewrinklereductionbenefitsofacosmeticniacinamide/peptide/retinylpropionateproductregimenvs.aprescription0,02%tretinoinproductregimenFuJ.,HillebrandG.,RaleighP.,LiJ.,MarmorM.,BertucciV.,GrimesP.,MandyS.,PerezM.,WeinkleS.andKaczvinskyJ.BrJDermatol,March;162(3):647–654,2010. Thesafetyandefficacyofpimecrolimus,1%,creamforthetreatmentofnethertonsyndromeYanA.C.,HonigP.J.,MingM.E.,WeberJ.andShahK.N.ArchDermatol,146(1):57-62,2010. AnovelorganogermaniumprotectedatopicdermatitisinducedbyoxazoloneLimD.H.,LiM.,SeoJ.-A.,LimK.-M.andHamS.W.BioorgMedChemLett,Jul15;20(14):4032-4034,2010. Adouble-blind,randomizedstudytoassesstheeffectivenessofdifferentmoisturizersinpreventingdermatitisinducedbyhandwashingtosimulatehealthcareuseWilliamsC.,WilkinsonS.,McShaneP.,LewisJ.,PenningtonD.,PierceS.andFernandezC.BrJDermatol,May;162(5):1088–1092,2010. ComparisonofskinbarrierfunctionandsensorynerveelectriccurrentperceptionthresholdbetweenIgE-highextrinsicandIgE-normalintrinsictypesofatopicdermatitisMoriT.,IshidaK.,MukumotoS.,YamadaY.,ImokawaG.,KabashimaK.,KobayashiM.,BitoT.,NakamuraM.,OgasawaraK.andTokuraY.BrJDermatol,Jan;162(1):83–90,2010. SkincareintheNICUpatient:EffectsofwipesversusclothandwateronstratumcorneumintegrityVisscherM.,OdioM.,TaylorT.,WhiteT.,SargantS.,SluderL.,SmithL.,FlowerT.,MasonB.,RiderM.,HuebnerA.andBondurantP.Neonatology,96(4):226-34,2009. Microbiologicalefficacyandtolerabilityofanew,non-alcohol-basedhanddisinfectantAgtheN.,TerhoK.,KurvinenT.,RoutamaaM.,PeltonenR.,LaitinenK.andKanervaM.InfectControlHospEpidemiol,Jul;30(7):685-90,2009. Glycylglycinedecreasesthesizeofconspicuousfacialpores:Single-blindedhalfareasofface-appliedstudyIidaT.,KanekoM.,KawaiE.,Muta-TakadaK.andInomataS.JDermatol,Feb;36(2):120-123,2009. RoleofTNF-polymorphism-308inirritantcontactdermatitisandneurosensoryresponseDavisJ.A.PhDThesis.Departmentofpharmaceuticalsciencesofthecollegeofpharmacy,UniversityofCincinnati,2009. CosmeceuticalpropertiesproducedbylevanproducedbyZymomonanmobilisKimK.H.,ChungC.B.,KimY.H.,KimK.S.,HanC.S.andKimC.H.JCosmetSci,56:395-406,2005. EvaluationoftheantioxidantcapacityandpreventiveeffectsofatopicalemulsionanditsvehiclecontrolontheskinresponsetoUVexposureZhaiH.,BehnamS.,VillaramaC.D.,Arens-CorellM.,ChoiM.J.andMaibachH.I.SkinPharmacolPhysiol,18:288-293,2005. EfficacyofdietaryhempseedoilinpatientswithatopicdermatitisCallawayJ.,SchwabU.,HarvimaI.,HalonenP.,MykkänenO.,HyvönenP.andJärvinenT.DermatologyTreat,16:87-94,2005. MoisturizingeffectsoftopicalnicotinamideonatopicdryskinSomaY.,KashimaM.,ImaizumiA.,TakahamaH.,KawakamiT.andMizoguchiM.IntJDermatol,Mar;44(3):197-202,2005. Abstracts InvestigationoftheefficacyofamoisturizerontheskinbarrierrecoveryinacaninemodelofmechanicalchronicbarrierdisruptionVidemontE.,GhibaudoG.andPinD.25thAnnualCongressoftheECVD-ESVD,Sep8-10,2011,Brussels,Belgium. Topicalcoconutoilapplicationreducestrans-epidermalwaterloss(TEWL)inpretermverylowbirthweightneonates:ArandomisedclinicaltrialNangiaS.,PaulV.K.andDeorariA.K.48thannualmeetingofESPRinPrague,CheckRepublic,6–8Oct2007,p.105.Pediatrics,Vol121Suppl2,Jan2008. Apilotstudyoftheefficacyandsafetyofpimecrolimus1%creaminthetreatmentofNethertonsyndrome:InterimresultsYanA.,ShahK.,KubrakC.andParneix-SpakeA.JAmAcadDermatol,February:AB153,2007. SusceptibilitytoSLSirritation:Effectofafive-daypre-useoftwoskincareoilsstudiedcomparingvarioustechniquesandinstrumentsRantanen,T.,Snellman,E.andKostiainenM.FirstWorldCongressonWork-RelatedandEnvironmentalAllergy,9-12July2003:p.95.  頭皮、唇、爪の測定 Functionalandstructuralage-relatedchangesinthescalpskinofCaucasianwomenFlorenceP.,CornillonC.,D'arrasM.-F.,FlamentF.,PanhardS.,DiridollouS.,andLoussouarnG.SkinResTechnol,epubMay5,2013. SeasonalfactorsinfluencingbiophysicalpropertiesoffacialandlabialskinGubanovaE.I.,Glad’koV.V.,CazeiL.,RodinaM.Yu.andLapatinaN.G.KlinDermatolVenerol,2:19-24,2010.Russian. Tapestrippingonahumannail:quantificationofremovalTudelaE.,LamberbourgA.,DiazA.C.,ZhaiH.andMaibachH.I.SkinResTechnol,14:472–477,2008. TheuseofanextendedventilationtubeasacountermeasureforEVA-associatedupperextremitymedicalissuesJonesJ.A.,HoffmanR.B.,BucklandD.A.,HarveyC.M.,BowenC.K.,HudyC.E.StraussS.,NovakJ.andGernhardtM.L.ActaAstronaut,63:763-768,2008. InfluenceofageandhormonereplacementtherapyonthefunctionalpropertiesofthelipsCaiseyL.,GubanovaE.,CamusC.,LapatinaN.,SmetnikV.andLévêqueJ.-L.SkinResTechnol,14:220-225,2008. Waterlossthroughlip,nail,eyelidskin,scalpskinandaxillarskinmeasuredwithaclosed-chamberevaporationprincipleNuutinenJ.,HarvimaI.,LahtinenM.-R.andLahtinenT.BrJDermatol,148:839-841,2003. Abstracts Shampooingwithpyrithionezincreducestransepidermalwaterlossinscalpofdandruff-involvedpatientsBillhimerW.,ErbJ.,BaconR.,ErtelKandCopasM.JAmAcadDermatol2006,54(3):Poster8 ComparisonoftwoinstrumentstoassessscalpbarrierfunctionBaconR.,Billhimer,W.,Ertel,K.andWatson,D.SkinResTechnol,Vol10:13,2004.   創傷治癒の研究 FliineutralizingantibodiesimprovewoundhealinginporcinepreclinicalstudiesJacksonJ.E.,KopeckiZ.,AdamsD.H.andCowinA.J.WoundRepairRegen,Vol20(4):523–536,2012. Humancell-conditionedmediaproducedunderembryonic-likeconditionsresultinimprovedhealingtimeafterlaserresurfacingZimberM.P.,MansbridgeJ.N.,TaylorM.,StocktonT.,HubkaM.,BaumgartnerM.,RheinsL.,HubkaK.,BrandtE.N.,KellarR.andNaughtonG.K.AestheticPlastSurg,Vol36(2):431-437,2012. Comparisonofasealed,polymerfoambiodegradabletemporizingmatrixagainstintegra®dermalregenerationtemplateinaporcinewoundmodelGreenwoodJ.E.andDearmanB.L.JBurnCareRes,Jan-Feb;33(1):163-173,2012. EpidermalwoundhealinginseveresepsisandsepticshockinhumansKoskelaM.,GäddnäsF.,Ala-KokkoT.I.,LaurilaJ.J.,SaarnioJ.,OikarinenA.andKoivukangasV.CritCare,Jun;13(3):R100,2009. InstrumentalevaluationoftheprotectiveeffectsofabarrierfilmonsurroundingskininchronicwoundsDiniV.,SalibraF.,BrilliC.andRomanelliM.Wounds,Sept;20:254-257,2008. Useofnanotechnology-designedfootsockinthemanagementofpreulcerativeconditionsinthediabeticfoot:resultsofasingle,blindrandomizedstudyBanchelliniE.,MacchiariniS.,DiniV.,RizzoL.,TedeschiA.,ScatenaA.,GorettiC.,CampiF.,RomanelliM.andAlbertoP.IntJLowExtremWounds,7:2:82-87,2008. Abstracts Moisturevapourtransmissionrate–Howisthisaffectedbywoundfluidviscosity?AdamsS.,PritchardD.andRogersJ.PosterpresentedatEuropeanWoundManagementAssociation2009,Finland. Evaluationofmacerationbytransepidermalwaterloss(TEWL)inpatientswithvenouslegulcersDiniV.,SalibraF.,BrilliC.,BertoneM.andRomanelliM.SumposiumonAdvancedWoundCare&MedicalReseachForumonWoundRepair,p.128,2006.   SkinsurfacewaterlossSSWL Abstracts Evaluationoflong-termperformanceutilizingahighabsorbencyadultincontinencebriefinalong-termcaresettinganditsimpactonoverallskinhealthKennedy-EvansK.L.,SalomonS.andBarbaK.InnovatingforContinence:TheEngineeringChallenge2011,Apr11-13,2011,Lincolnshire,Illinois. Theeffectofdifferentincontinence“gel-based”briefsonskinbarrierfunctionininstitutionalisedadultsSalomonS.,MilneC.T.,SaucierD.andBarbaK.InnovatingforContinence:TheEngineeringChallenge2011,Apr11-13,2011,Lincolnshire,Illinois. MeasurementofskinhydrationinthediaperedareaofinfantswithaclosedchamberTEWLmeterAlanen,E.,Wiesemann,F.,Nuutinen,J.andLahtinen,T.SkinResTechnol,Vol9(2):199,2003.   TransonychialwaterlossTOWL  Tapestrippingonahumannail:quantificationofremovalTudelaE.,LamberbourgA.,DiazA.C.,ZhaiH.andMaibachH.I.SkinResTechnol,14:472–477,2008. TheuseofanextendedventilationtubeasacountermeasureforEVA-associatedupperextremitymedicalissuesJonesJ.A.,HoffmanR.B.,BucklandD.A.,HarveyC.M.,BowenC.K.,HudyC.E.StraussS.,NovakJ.andGernhardtM.L.ActaAstronaut,63:763-768,2008. Waterlossthroughlip,nail,eyelidskin,scalpskinandaxillarskinmeasuredwithaclosed-chamberevaporationprincipleNuutinenJ.,HarvimaI.,LahtinenM.-R.andLahtinenT.BrJDermatol,148:839-841,2003.   生理学、交感神経皮膚反応、多汗状態 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In-vitro試験 EffectsofeightvehiclesontransdermallidocainepenetrationinsheepskininvitroBayldonW.,NarishettyS.,DeRoseG.,RothwellJ.andMillsP.C.JVetPharmacol,epubAug28,2013. RoleofpartitioncoefficientsindeterminingthepercutaneouspenetrationofsalicylicacidandformaldehydeundervaryingocclusiondurationsHafeezF.,ChiangA.,HuiX.andMaibachH.DrugDevIndPharm,epubAug12,2013. HumanskininvitropermeationofbentazonandisoproturonformulationswithorwithoutprotectiveclothingsuitBerthetA.,HopfN.P.,MilesA.,SpringP.,CharrièreN.,GarrigouA.,BaldiI.andVernezD.ArchToxicol,epubJul3,2013. Cutaneousdeliveryofα-tocopherolandlipoicacidusingmicroemulsions:influenceofcompositionandchargeCichewiczA.,PaclebC.,ConnorsA.,HassM.A.andLopesL.B.JPharmPharmacol,Jun;65(6):817–26,2013. StratumcorneumdryingdrivesverticalcompressionandlipidorganizationandimprovesbarrierfunctioninvitroIwaiI.,KunizawaN.,YagiE.,HiraoT.andHattaI.ActaDermVenereol,93:138-43,2013. Dermalexposuretomethamphetaminehydrochloridecontaminatedresidentialsurfaces:SurfacepHvalues,volatility,andinvitrohumanskinSalocksC.B.,HuiX.,LamelS.,QiaoP,SanbornJ.R.andMaibachH.I.FoodChemToxicol,Vol50(12):4436–40,2012. Changesinceramidesandglucosylceramidesinmouseskinandhumanepidermalequivalentsbyrice-derivedglucosylceramideShimodaH.,TerazawaS.,HitoeS.,TanakaJ.,NakamuraS.,MatsudaH.andYoshikawaM.JMedFood,15(12):1064-1072,2012. Influenceofapore-formingagentonswelling,networkparameters,andpermeabilityofpoly(ethyleneglycol)-crosslinkedpoly(methylvinylether-co-maleicacid)hydrogels:ApplicationintransdermaldeliverysystemsRajSinghT.R.,GarlandM.J.,MigalskaK.,SalvadorE.C.,ShaikhR.,McCarthyH.O.,WoolfsonD.A.andDonnellyR.F.JApplPolymSci,Aug;125(4):2680–2694,2012. Rheologicalcharacterizationofaxanthan-galactomannanhydrogelloadedwithlipophilicsubstancesKoopH.S.,Da-LozzoE.J.,deFreitasR.A.,FrancoC.R.,MitchellD.A.andSilveiraJ.L.JPharmSci,Jul;101(7):2457-2467,2012. LowfrequencysonophoresismediatedtransdermalandintradermaldeliveryofketoprofenHerwadkarA.,SachdevaV.,TaylorL.F.,SilverH.andBangaA.K.IntJPharm,Feb;423(2):289-296,2012. Structure-skinpermeabilityrelationshipofdendrimersVenugantiV.V.,SahdevP.,HildrethM.,GuanX.andPerumalO.PharmRes,Sep;28(9):2246-2260,2011. EnhanceddermaldeliveryofacyclovirusingsolidlipidnanoparticlesJainS.,MistryM.A.andSwarnakerN.K.DrugDelTransRes,5(1):395-406,2011. Skinpenetrationanddepositionofcarboxyfluoresceinandtemoporfinfromdifferentlipidvesicularsystems:InvitrostudywithfiniteandinfinitedosageapplicationChenM.,LiuX.andFahA.IntJPharm,Apr15;408(1-2):223-234,2011. Magnetophoresisforenhancingtransdermaldrugdelivery:MechanisticstudiesandpatchdesignMurthy,S.N.,SammetaS.M.andBowersC.JournalofControlledRelease,Dec1;148(2):197-203,2010. SkindeliveryofferulicacidfromdifferentvesicularsystemChenM.,LiuX.andFahrA.JBiomedNanotechnol,Oct;6(5):577-585,2010. EvaluationneedlelengthanddensityofmicroneedlearraysinthepretreatmentofskinfortransdermaldrugdeliveryYanG.,WarnerK.S.,ZhangJ.,SharmaS.andGaleB.K.IntJPharm,May31;391(1-2):7-12,2010. Microchannelscreatedbysugarandmetalmicroneedles:Characterizationbymicroscopy,macromolecularfluxandothertechniquesLiG.,BadkarA.,KalluriH.andBangaA.K.JPharmSci,Apr;99(4):1931-41,2010. Transdermaliontophoreticdeliveryofterbinafinehydrochloride:QuantitationofdruglevelsinstratumcorneumandunderlyingskinSachdevaV.,SiddojuS.,YuY.-Y.,KimH.D.,FridenP.M.andBangaA.K.IntJPharm,Mar;388(1-2),24-31,2010. Transdermalandintradermaliontophoreticdeliveryofdexamethasonesodiumphosphate:quantificationofthedruglocalizedinskinPaturiJ.,KimH.D.,ChakrabortyB.,FridenP.M.andBangaA.K.JDrugTarg,Feb;18(2):134-140,2010. Transdermaldeliveryoffentanylfrommatrixandreservoirsystems:EffectofheatandcompromisedskinProdduturiS.,SadriehN.,WokovichA.M.,DoubW.H.,WestenbergerB.J.andBuhseL.JPharmSci,99:2357–2366,2010. MicroneedlearraysallowlowermicrobialpenetrationthanhypodermicneedlesinvitroDonnellyR.F.,SinghT.R.R.,TunneyM.M.,MorrowD.I.J.,McCarronP.A.,O’MahonyC.andWoolfsonA.D.PharmRes,Nov;26(11):2513–2522,2009. Poly(amidoamine)dendrimersasskinpenetrationenhancers:Influenceofcharge,generation,andconcentration.VenugantiV.V.K.andPerumalO.P.JPharmSci,Jul;98(7):2345–2356,2009. OcuDrain-E™-Anoninvasivetechniqueforreductionofintraocularpressure.MurthyS.M.,SammetaS.M.andVakaS.R.K.IntJPharm,Mar;369(1-2):92-95,2009. Skinpenetrationenhancementbyamicroneedledevice(Dermaroller®)invitro:DependencyonneedlesizeandappliedformulationBadranM.M.,KuntscheJ.andFahrA.EurJPharmSci,Mar;36(4-5):511-523,2009. Reservoirbasedfentanyltransdermaldrugdeliverysystems:effectofpatchageondrugreleaseandskinpermeationProdduturiS.,SmithG.J.,WokovichA.M.,DoubW.H.,WestenbergerB.J.andBuhseL.PharmRes,26:6,2009. Molecularchargemediatedtransportofa13kDproteinacrossmicroporatedskinKatikaneniS.,BadkarA.,NemaS.andBangaA.K.IntJPharm,378:93–100,2009. Filmsbasedonchitosanpolyelectrolytecomplexesforskindrugdelivery:DevelopmentandcharacterizationSilvaC.L.,PereiraJ.C.,RamalhoA.,PaisA.C.C.C.andSousaJ.J.S.JMembSci,320:268-279,2008. Effectofpoly(amidoamine)(PAMAM)dendrimeronskinpermeationof5-fluorouracilVenugantiV.V.K.andPerumalO.P.IntJPharm,361:230-238,2008. InteractionoflipidnanoparticleswithhumanepidermisandanorganotypiccellculturemodelKuntscheJ.,BunjesH.,FahrA.,PappinenS.,RönkköS.,SuhonenM.andUrttiA.IntJPharm,354:180-195,2008. QualitativeandquantitativecomparisonofheatseparatedepidermisanddermatomedskininpercutaneousabsorptionstudiesAtrux-TallauN.,PirotF.,FalsonF.,RobertsM.S.andMaibachH.I.ArchDermatolRes,299:507-511,2007. Invitrohumanskinmodeltoevaluatewaterpermeabilityanddeterminewounddressings'occlusivityZhaiX.,YokotaM.andMaibachH.I.CutanOculToxicol,26(2):107-11,2007. VitaminCenhancesdifferentationofacontinuouskeratinocytecellline(REK)intoepidermiswithnormalstratumcornuemultrasructureandfunctionalpermeabilitybarrierPasonen-SeppänenS.,SuhonenT.M.,KirjavainenM.,SuihkoE.,UrttiA.,MiettinenM.,HyttinenM.,TammiM.andTammiR.HistocemCellBiol,116:287-297,2001.14FormationofpermeabilitybarrierinepidermalorganotypiccultureforstudiesondrugtransportPasonen-SeppänenS.,SuhonenT.M.,KirjavainenM.,MiettinenM.,UrttiA.,TammiM.andTammiR.JInvestDermatol,Nov;117(5):1322-1324,2001. Abstracts Comparativedermalpenetrationstudiesinhumanfull-thicknessanddermatomedskinGuthK.,Schäfer-KortingM.,FabianE.,vanRavenzwaayB.andLandsiedelR.PosterpresentedatSkinForum12thAnnualMeeting;28-29Mar2011.   バリデーション試験 Internationalguidelinesfortheinvivoassessmentofskinpropertiesinnon-clinicalsettings:Part2.transepidermalwaterlossandskinhydrationduPlessisJ.,StefaniakA.,EloffF.,JohnS.,AgnerT.,ChouT.-C.,NixonR.,SteinerM.,FrankenA.,KudlaI.andHolnessL.SkinResTechnol,Aug;19(3):265-78,2013. Side-by-sidecomparisonofanopen-chamber(TM300)andaclosed-chamber(Vapometer™)transepidermalwaterlossmeterSteinerM.,Aikman-GreenS.,PrescottG.J.andDickF.D.SkinResTechnol,Aug;17(3):366-72,2011. Tape-strippingmethodinman:comparisonofevaporimetricmethodsZhaiH.,DikaE.,GoldovskyM.andMaibachH.I.SkinResTechnol,May;13(2):207-10,2007. Measurementoftransepidermalwaterlossbyclosed-chambersystemsNuutinenJ.inSerupJ.,JemecG.B.E.andGroveG.,(eds.),Handbookofnon-invasivemethodsandtheskin,2ndedition,CRCPress,BocaRaton,FL,pp.393-396,2006. ComparativeevaporimetryinmanShahJ.H.,ZhaiH.andMaibachH.I.SkinResTechnol,Aug;11(3):205-8,2005. ValidationoftheVapoMeter,aclosedunventilatedchambersystemtoassesstransepidermalwaterlossvs.theopenchamberTewameterDePaepeK.,HoubenE.,AdamR.,WieswmannF.andRogiersV.SkinResTechnol,Feb;11(1):61-9,2005. Waterlossthroughlip,nail,eyelidskin,scalpskinandaxillarskinmeasuredwithaclosed-chamberevaporationprincipleNuutinenJ.,HarvimaI.,LahtinenM.-R.andLahtinenT.BrJDermatol,148:839-841,2003. AclosedunventilatedchamberforthemeasurementoftransepidermalwaterlossNuutinenJ.,AlanenE.,AutioP.,LahtinenM-R.,HarvimaI.andLahtinenT.SkinResTechnol,May;9(2):85-9,2003. Abstracts ApplicabilityoftheclosedunventilatedVapoMetertoassesstransepidermalwaterloss(TEWL)onnasolabialskinareasDePaepe,K.,Houben,E.,Adam,R.,Wiesemann,F.andRogiers,V.SkinResTechnol,Vol10:3,2004. ComparisonoftwomethodsforTEWLmeasurementShahJ.H.,ZhaiH.,MaibachH.I.andNuutinenJ.SkinResTechnol,Vol10,2004. MeasurementofwaterevaporationrateswithaclosedchamberTEWLmeterNuutinen,J.,Alanen,E.andLahtinen,T.SkinResTechnol,Vol9(2):183,2003.  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