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Trials is dedicated to improving the design, conduct and reporting of randomised controlled trials in health. Edited by an internationally renowned ... Skiptomaincontent Advertisement SearchallBMCarticles Search COVID-19 Callforpapers:ImpactofCOVID-19onclinicaltrials Trials is invitingsubmissionofmanuscripts,longandshort,includingLettersandCommentaries detailingtheenforcedchangestotrialdesign;trialmanagement;recruitment;consentprocess;interventiondeliveryandfollowupasa resultoftheCOVID-19pandemic.Wealsowelcomesubmissionof Updates toprotocolspreviouslypublishedin Trials thatdescribechangesmadebecauseoftheCOVID-19pandemic. ReadMore Articles Recent Mostaccessed Effectofhigh-flownasaltherapyonpatient-centredoutcomesinpatientsathighriskofpostoperativepulmonarycomplicationsaftercardiacsurgery:astudyprotocolforamulticentreadaptiverandomisedcontrolledtrial Authors:MelissaEarwaker,SofiaVillar,JuliaFox-Rushby,MelissaDuckworth,SarahDawson,JoSteele,Yi-daChiu,EdwardLitton,GudrunKunst,GavinMurphy,GuillermoMartinez,VasileiosZochios,ValBrown,GeoffBrownandAndrewKlein Contenttype:Studyprotocol 28March2022 Effectofvaginalantisepticpriortocaesareansectionontherateofpost-caesareancomplications:ablindedrandomisedcontrolledtrial Authors:MonikaTrivedi,AinsleyM.RobinsonandMdRafiqulIslam Contenttype:Studyprotocol 24March2022 Effectivenessofamobileapp-basededucationalinterventiontotreatinternetgamingdisorderamongIranianadolescents:studyprotocolforarandomizedcontrolledtrial Authors:AmirH.Pakpour,SaraFazeli,IsaMohammadiZeidi,ZainabAlimoradi,MattiasGeorgsson,AndersBrostromandMarcN.Potenza Contenttype:Studyprotocol 21March2022 ChineseherbalformulaTongxieYaofangfordiarrhea-predominantirritablebowelsyndrome:studyprotocolforarandomized,multiple-blind,placebo-controlledtrial Authors:Shi-BingLiang,MeiHan,Hong-JieCheng,Qiao-YanZhang,Nai-WeiZhang,Bo-YiJia,NicolaRobinsonandJian-PingLiu Contenttype:Studyprotocol 21March2022 Pediatricspecificchallengesofthesingleinstitutionalreviewboardmandate Authors:AndrewHu,JaneL.HollandMehulV.Raval Contenttype:Commentary 21March2022 MostrecentarticlesRSS Viewallarticles Throughthelookingglass:understandingnon-inferiority Authors:JenniferSchumiandJanetTWittes Contenttype:Review 3May2011 Samplesizerequirementstoestimatekeydesignparametersfromexternalpilotrandomisedcontrolledtrials:asimulationstudy Authors:MDawnTeare,MunyaradziDimairo,NeilShephard,AlexHayman,AmyWhiteheadandStephenJWalters Contenttype:Research 3July2014 Managingclinicaltrials Authors:BarbaraFarrell,SaraKenyonandHaleemaShakur Contenttype:Review 13July2010 Palliativelong-termabdominaldrainsversusrepeateddrainageinindividualswithuntreatableascitesduetoadvancedcirrhosis:studyprotocolforafeasibilityrandomisedcontrolledtrial Authors:LuciaMacken,LouiseMason,CatherineEvans,HeatherGage,JakeJordan,MarkAustin,NickParnell,MaxCooper,ShaniSteer,JustineBoles,StephenBremner,DebbieLambert,DavidCrook,GemmaEarl,JeanTimeyinandSumitaVerma Contenttype:Studyprotocol 27July2018 The Correctiontothisarticlehasbeenpublishedin Trials 2018 19:488 Reportingbiasinmedicalresearch-anarrativereview Authors:NatalieMcGauran,BeateWieseler,JuliaKreis,Yvonne-BeatriceSchüler,HeikeKölschandThomasKaiser Contenttype:Review 13April2010 MostaccessedarticlesRSS Viewallarticles Blogs WorldOralHealthDay2022:PartneringtoimprovetheoralhealthofAboriginalandTorresStraitIslanderadolescents 17March2022 RareDiseaseDay2022:howcanweimproveresearchinrarediseases? 24February2022 BMCSeriesHighlightsBlog–January2022 24February2022 ReadMore Articlecollections ThematicseriesThefutureofpragmatictrialsEditedbyProfMarionCampbellandProfSandraEldridgeThematicseriesBigdataforrandomizedtrialsEditedbyDrLarsHemkensArticlecollectionSamplesizecalculationsandspecifyingthetargetdifferenceforrandomizedtrialsThematicseriesBuildingcapacityforevidenceinformedtrialmanagementEditedbyDrRobertaLittlefordandProfShaunTreweekThematicseriesSteppedwedgerandomizedcontrolledtrialsEditedbyProfDavidTorgersonViewallarticlecollections Trendingarticles Clickheretoviewwhicharticleshavebeensharedthemostinthelastmonth! LatestSupplement Meetingabstractsfromthe5thInternationalClinicalTrialsMethodologyConference(ICTMC2019) InReview:anintegratedpre-printserviceforTrials Trials,inpartnershipwithResearchSquare,isnowofferingInReview,aservice thatallowsauthorstooptintouploadtheirmanuscripttoafreepreprintplatformwhensubmittingtoSpringerNaturejournals.Thisserviceallowsauthorsto:• Sharetheirworkwithfellowresearcherstoread,commenton,andciteevenbeforepublication• ShowcasetheirworktofundersandotherswithacitableDOIwhileitisstillunderreview• Tracktheirmanuscript-includingseeingwhenreviewersareinvited,andwhenreportsarereceived ReadMore Callforpapers:CasestudiesofexperiencewithinterimdataandIDMCsinRCTs Editedby:ProfMatthewSydes(MRCClinicalTrialsUnitatUCL) Submissionsoncomplementaryandalternativemedicine Asajournaldedicatedtoimprovethereportingandpublicationofclinicaltrials,weaimtoembraceallcontentthatisrelevant,includinggeneralmethodologypapers,andresearchintothetrialprocesses,protocolsandstatisticalanalysisplanforrandomizedcontrolledtrials,aswellastraditionalresearchandcommentarypapers.However,itrequiresanin-depthsubjectknowledgetoproperlyevaluatepapersonthetopicofcomplementaryandalternativemedicinetoassesstheintervention,thedesignofthetrials,aswellastheprimaryandsecondaryoutcomes.Hencewefeelit’sbettertoreferauthorsofthesepaperstothejournalsthataremoreequippedwiththeexpertiserequired.Asof 1st September2021,Trialswillnolongerbeconsideringpapersonthetopicofcomplementaryandalternativemedicine.WerecommendthebelowjournalsfromtheBMCfamilythatcanaccommodatestudiesinthisarea,dopleasecheckeachjournalscopecarefullybeforesubmitting:・BMCComplementaryMedicineandTherapies (acceptingstudyprotocols)・ChineseMedicine・NutritionJournal (acceptingstudyprotocols)Submissionsmadeafter1stSeptemberwillbereferredtoTransferDeskteamwhowillhelptheauthorsselectaproperdestinationfortheirmanuscript. LinkyourpublicationswithanORCiDidentifier TrialswouldliketoaskallauthorstoincludetheirORCiDidentifierwhensubmittingtheirworktoTrials.AnORCiD(OpenResearcherandContributorID)numberuniquelyattachesyouridentitytoyourresearchwork,suchasyourarticlesanddatasets.Youcangetyourfreepersonalidentifier​athttps://ORCiD.org/register. StructuredStudyProtocols Trials isexperimentingwithanewwayofstructuringstudyprotocolsforrandomisedtrials.Thesimpleinnovationistoincludeall51SPIRITheadingsanditemidentifierswithintheprotocolitself.Readerswillthenbenefitfromtheabilitytosearchbyitemidentifier,whicharecontainedwithincurlybrackets.Thisisnotmandatoryandwewillcontinuetoconsiderprotocolssubmittedinotherformats.WehavecreatedatemplateforthisnewformatthatcontainsbothSPIRITand Trials guidanceinoneplace. ReadMore Aimsandscope Trialsencompassesallaspectsoftheperformanceandfindingsofrandomizedcontrolledtrialsinhealth.Wepublisharticlesongeneraltrialmethodologyandresearchintotrialprocesses,aswellasstudyprotocolsandstatisticalanalysisplansforrandomizedcontrolledtrials,commentariesandtraditionalresultspapers-regardlessofoutcomeorsignificanceoffindings.Readmore Peerreviewmentoring TheEditorsendorsepeerreviewmentoringofearlycareerresearchers.Findoutmorehere Thankyoutoourpeerreviewers TheeditorsandstaffofTrialswouldliketowarmlythankourpeerreviewerswhosecommentshavehelpedtoshapethejournal. LatestTweets ViewTwittertimeline YourbrowserneedstohaveJavaScriptenabledtoviewthistimeline AbouttheEditors PeterJüni,Editor-in-ChiefPeterisaclinicalepidemiologistandgeneralinternist,andtheDirectoroftheAppliedHealthResearchCentre(AHRC)attheLiKaShingKnowledgeInstituteofSt.Michael’sHospital.HeholdsaTier1CanadaResearchChairinClinicalEpidemiologyofChronicDiseasesandisaProfessorattheDepartmentofMedicineandtheInstituteofHealthPolicy,ManagementandEvaluationattheUniversityofToronto.Peterisknownforhismethodologicalworkandforhisclinicalresearchonthemanagementofcardiovascularandmusculoskeletaldisorders.Hehashadleadingrolesinmajorcardiovasculartrials,servedasamemberofseveraltaskforcesoftheEuropeanSocietyofCardiology,andcontributedtotheCochraneRiskofBiastoolsforrandomizedandnon-randomizedstudies. TianjingLi,Editor-in-ChiefTianjingisanAssociateProfessorintheDepartmentofEpidemiologyatJohnsHopkinsBloombergSchoolofPublicHealth(JHBSPH).DrLiwastrainedasaphysicianandsubsequentlyearnedherPhDinEpidemiology(ClinicalTrialsconcentration)andMHSinBiostatisticsfromJHBSPH. TheprimarygoalofDrLi'sresearchistodevelop,evaluate,anddisseminateefficientmethodsforcomparinghealthcareinterventionsandtoprovidetrustworthyevidencefordecisionmaking.Hercoreresearchinterestsincludemethodologiesforrandomizedcontrolledtrials,systematicreviews,networkmeta-analysis,comparativeeffectivenessresearch,andpatient-centeredoutcomesresearch.DrLiservesastheAssociateDirectorforCochraneUnitedStatesandtheDirectorforResearchforCochraneEyesandVisionUSProject. ShaunTreweek,Editor-in-ChiefShaunisProfessorofHealthServicesResearchintheHealthServicesResearchUnitattheUniversityofAberdeen,UK. ProfTreweek’sresearchinterestsaremainlyinefficienttrialdesign,particularlypragmatictrialdesign,improvedrecruitmentandretentioninterventionsfortrials,thedesignofstudiestogeneratetrialprocessevidenceandtheeffectivepresentationofresearchevidence. HeisleadinganinitiativecalledTrialForge(http://www.trialforge.org)thataimstobemoresystematicabouthowwegenerateanduseresearchevidenceinmakingtrialdesign,conduct,analysisandreportingdecisions.  Advertisement Submitmanuscript EditorialBoard InstructionsforEditors Instructionsforauthors Signupforarticlealertsandnewsfromthisjournal Follow FollowusonTwitter AnnualJournalMetrics Speed132daystofirstdecisionforallmanuscripts118 daystofirstdecisionforreviewedmanuscriptsonly170daysfromsubmissiontoacceptance31daysfromacceptancetopublicationCitationImpact2.279- 2-yearImpactFactor2.606 - 5-yearImpactFactor0.930 - SourceNormalizedImpact perPaper(SNIP)1.067-SCImagoJournalRank(SJR)Usage 6,233,603Downloads(2021)5,758AltmetricMentions Moreaboutourmetrics Advertisement Trials ISSN:1745-6215 Contactus Submissionenquiries:AccesshereandclickContactUs Generalenquiries:[email protected]