tobi protein (Drosophila melanogaster) - STRING interaction ...

tobi, Target of brain insulin; Alpha-1,4-glucosidase activity. ... Alpha-amylase; Amylase distal is one of three amylases encoded in the Drosophila genome. https://version-11-5.string-db.org/cgi/network?networkId=bBANRK7olGAd STRINGDatabaseUserSurvey Pleasehelpusimprovefurther—takeamomenttofillourbriefusersurvey.  11.5LoginRegisterSurveySTRINGSTRINGSearchDownloadHelpMy Data ViewersLegendSettingsAnalysisExportsClustersMoreLessloading...currentlyshowingNetworkSummaryview:showscurrentinteractions.Nodescanbemoved;popupsprovideinformationonnodes&edges. loading...currentlyshowingNeighborhoodGroupsofgenesthatarefrequentlyobservedineachother'sgenomicneighborhood. loading...currentlyshowingExperimentsCo-purification,co-crystallization,Yeast2Hybrid,GeneticInteractions,etc...asimportedfromprimarysources. loading...currentlyshowingCooccurrenceGenefamilieswhoseoccurrencepatternsacrossgenomesshowsimilarities. loading...currentlyshowingDatabasesKnownmetabolicpathways,proteincomplexes,signaltransductionpathways,etc...fromcurateddatabases. loading...currentlyshowingCoexpressionProteinswhosegenesareobservedtobecorrelatedinexpression,acrossalargenumberofexperiments. loading...currentlyshowingTextminingAutomated,unsupervisedtextmining-searchingforproteinsthatarefrequentlymentionedtogether. loading...currentlyshowingFusionGenesthataresometimesfusedintosingleopenreadingframes. STRINGallowsinspectionoftheinteractionevidenceforanygivennetwork.Chooseanyoftheviewersabove(disabledifnotapplicableinyournetwork).Nodes:Networknodesrepresentproteinsspliceisoformsorpost-translationalmodificationsarecollapsed,i.e.eachnoderepresentsalltheproteinsproducedbyasingle,protein-codinggenelocus.NodeColorcolorednodes:queryproteinsandfirstshellofinteractorswhitenodes:secondshellofinteractorsNodeContentemptynodes:proteinsofunknown3Dstructurefillednodes:some3DstructureisknownorpredictedEdges:Edgesrepresentprotein-proteinassociationsassociationsaremeanttobespecificandmeaningful,i.e.proteinsjointlycontributetoasharedfunction;thisdoesnotnecessarilymeantheyarephysicallybindingtoeachother.KnownInteractionsfromcurateddatabasesexperimentallydeterminedPredictedInteractionsgeneneighborhoodgenefusionsgeneco-occurrenceOtherstextminingco-expressionproteinhomology YourInput:NeighborhoodGeneFusionCooccurenceCoexpressionExperimentsDatabasesTextmining[Homology]Score tobiTargetofbraininsulin;Alpha-1,4-glucosidaseactivity.Itisinvolvedinthebiologicalprocessdescribedwith:carbohydratemetabolicprocess;Belongstotheglycosylhydrolase31family(657aa)    PredictedFunctionalPartners:Mal-A8Alpha-glucosidase;MaltaseA8;Cationbinding;alpha-1,4-glucosidaseactivity.Itisinvolvedinthebiologicalprocessdescribedwith:carbohydratemetabolicprocess     0.869 Mal-A7MaltaseA7,isoformA;Cationbinding;alpha-1,4-glucosidaseactivity.Itisinvolvedinthebiologicalprocessdescribedwith:carbohydratemetabolicprocess     0.867 Mal-A1Alpha-glucosidase;MaltaseA1;Cationbinding;catalyticactivity;alpha-1,4-glucosidaseactivity.Itisinvolvedinthebiologicalprocessdescribedwith:carbohydratemetabolicprocess;glucosemetabolicprocess;Belongstotheglycosylhydrolase13family     0.817 Amy-pAmylaseproximal,isoformb;Alpha-amylaseB;AmylaseproximalisoneofthreeamylasesencodedintheDrosophilagenome.Itisadigestiveenzymerequiredforthehydrolysisofdietarystarch     0.808 Amy-dAlpha-amylase;AmylasedistalisoneofthreeamylasesencodedintheDrosophilagenome.Itisadigestiveenzymerequiredforthehydrolysisofdietarystarch     0.807 Mal-A2Alpha-glucosidase;MaltaseA2;Cationbinding;catalyticactivity;alpha-1,4-glucosidaseactivity.Itisinvolvedinthebiologicalprocessdescribedwith:carbohydratemetabolicprocess;glucosemetabolicprocess;Belongstotheglycosylhydrolase13family     0.782 TalProbabletransaldolase;Transaldolaseisimportantforthebalanceofmetabolitesinthepentose-phosphatepathway    0.702 Mal-A6MaltaseA6,isoformC;Cationbinding;catalyticactivity.Itisinvolvedinthebiologicalprocessdescribedwith:carbohydratemetabolicprocess     0.683 CG9485CG9485,isoformB;Amylo-alpha-1,6-glucosidaseactivity;4-alpha-glucanotransferaseactivity.Itisinvolvedinthebiologicalprocessdescribedwith:glycogenbiosyntheticprocess;glycogencatabolicprocess      0.663 AGBE1,4-Alpha-GlucanBranchingEnzymeisahydrolaseinvolvedindeterminationoflifespan,glycogenbiosynthesisandhypoxia     0.659 YourCurrentOrganism:DrosophilamelanogasterNCBItaxonomyId:7227Othernames:D.melanogaster,fruitfly Basic Settings Networktype: fullSTRINGnetwork( theedgesindicatebothfunctionalandphysicalproteinassociations) physicalsubnetwork( theedgesindicatethattheproteinsarepartofaphysicalcomplex) meaningofnetworkedges: evidence(   linecolorindicatesthetypeofinteractionevidence) confidence(   linethicknessindicatesthestrengthofdatasupport) activeinteractionsources:TextminingExperimentsDatabasesCo‑expression NeighborhoodGeneFusionCo‑occurrence minimumrequiredinteractionscore:highestconfidence(0.900)highconfidence(0.700)mediumconfidence(0.400)lowconfidence(0.150)customvalueconfidence:   maxnumberofinteractorstoshow:1st shell:  -none/queryproteinsonly-nomorethan5interactorsnomorethan10interactorsnomorethan20interactorsnomorethan50interactorscustomvaluemax interactors:  2nd shell:  -none-nomorethan5interactorsnomorethan10interactorsnomorethan20interactorsnomorethan50interactors  customvaluemax interactors:   UpdateAdvanced Settingsnetworkdisplaymode:staticpng(   networkisasimplebitmapimage;notinteractive)interactivesvg(   networkisascalablevectorgraphic[SVG];interactive) networkdisplayoptions:disablestructurepreviewsinsidenetworkbubbleshidedisconnectednodesinthenetworkshowinputproteinnameshideproteinnames &nbspSendnetworktoCytoscape Exportyourcurrentnetwork:...asabitmapimage:downloadfileformatis'PNG':portablenetworkgraphic...asahigh-resolutionbitmap:downloadsamePNGformat,butathigherresolution...asavectorgraphic:downloadSVG:scalablevectorgraphic-canbeopenedandeditedinIllustrator,CorelDraw,Dia,etc...asshorttabulartextoutput:downloadTSV:tabseparatedvalues-canbeopenedinExcelandCytoscape(listsonlyone-wayedges:A-B)...astabulartextoutput:downloadTSV:tabseparatedvalues-canbeopenedinExcel(listsreciprocaledges:A-B,B-A)...asanXMLsummary:downloadstructuredXMLinteractiondata,accordingtothe'PSI-MI'datastandard...proteinnodedegrees:downloadnodedegreeofproteinsinyournetwork(giventhecurrentscorecut-off)...networkcoordinates:downloadaflat-fileformatdescribingthecoordinatesandcolorsofnodesinthenetwork...proteinsequences:downloadMFA:multi-fastaformat-containingtheaminoacidsequencesinthenetwork...proteinannotations:downloadatab-delimitedfiledescribingthenames,domainsanddescriptionsofproteinsinyournetwork Browseinteractionsintabularform:node1node2node1accessionnode2accessionnode1annotationnode2annotationscoreAGBEAmy-dFBpp0086845FBpp00861361,4-Alpha-GlucanBranchingEnzymeisahydrolaseinvolvedindeterminationoflifespan,glycogenbiosynthesisandhypoxiaAlpha-amylase;AmylasedistalisoneofthreeamylasesencodedintheDrosophilagenome.Itisadigestiveenzymerequiredforthehydrolysisofdietarystarch0.940 AGBEAmy-pFBpp0086845FBpp00861551,4-Alpha-GlucanBranchingEnzymeisahydrolaseinvolvedindeterminationoflifespan,glycogenbiosynthesisandhypoxiaAmylaseproximal,isoformb;Alpha-amylaseB;AmylaseproximalisoneofthreeamylasesencodedintheDrosophilagenome.Itisadigestiveenzymerequiredforthehydrolysisofdietarystarch0.939 AGBECG9485FBpp0086845FBpp00715261,4-Alpha-GlucanBranchingEnzymeisahydrolaseinvolvedindeterminationoflifespan,glycogenbiosynthesisandhypoxiaCG9485,isoformB;Amylo-alpha-1,6-glucosidaseactivity;4-alpha-glucanotransferaseactivity.Itisinvolvedinthebiologicalprocessdescribedwith:glycogenbiosyntheticprocess;glycogencatabolicprocess0.999 AGBEMal-A1FBpp0086845FBpp00878381,4-Alpha-GlucanBranchingEnzymeisahydrolaseinvolvedindeterminationoflifespan,glycogenbiosynthesisandhypoxiaAlpha-glucosidase;MaltaseA1;Cationbinding;catalyticactivity;alpha-1,4-glucosidaseactivity.Itisinvolvedinthebiologicalprocessdescribedwith:carbohydratemetabolicprocess;glucosemetabolicprocess;Belongstotheglycosylhydrolase13family0.416 AGBEMal-A2FBpp0086845FBpp00878261,4-Alpha-GlucanBranchingEnzymeisahydrolaseinvolvedindeterminationoflifespan,glycogenbiosynthesisandhypoxiaAlpha-glucosidase;MaltaseA2;Cationbinding;catalyticactivity;alpha-1,4-glucosidaseactivity.Itisinvolvedinthebiologicalprocessdescribedwith:carbohydratemetabolicprocess;glucosemetabolicprocess;Belongstotheglycosylhydrolase13family0.415 AGBEMal-A7FBpp0086845FBpp00878361,4-Alpha-GlucanBranchingEnzymeisahydrolaseinvolvedindeterminationoflifespan,glycogenbiosynthesisandhypoxiaMaltaseA7,isoformA;Cationbinding;alpha-1,4-glucosidaseactivity.Itisinvolvedinthebiologicalprocessdescribedwith:carbohydratemetabolicprocess0.415 AGBEMal-A8FBpp0086845FBpp00878311,4-Alpha-GlucanBranchingEnzymeisahydrolaseinvolvedindeterminationoflifespan,glycogenbiosynthesisandhypoxiaAlpha-glucosidase;MaltaseA8;Cationbinding;alpha-1,4-glucosidaseactivity.Itisinvolvedinthebiologicalprocessdescribedwith:carbohydratemetabolicprocess0.413 AGBETalFBpp0086845FBpp00720501,4-Alpha-GlucanBranchingEnzymeisahydrolaseinvolvedindeterminationoflifespan,glycogenbiosynthesisandhypoxiaProbabletransaldolase;Transaldolaseisimportantforthebalanceofmetabolitesinthepentose-phosphatepathway0.711 AGBEtobiFBpp0086845FBpp00842211,4-Alpha-GlucanBranchingEnzymeisahydrolaseinvolvedindeterminationoflifespan,glycogenbiosynthesisandhypoxiaTargetofbraininsulin;Alpha-1,4-glucosidaseactivity.Itisinvolvedinthebiologicalprocessdescribedwith:carbohydratemetabolicprocess;Belongstotheglycosylhydrolase31family0.659 Amy-dAGBEFBpp0086136FBpp0086845Alpha-amylase;AmylasedistalisoneofthreeamylasesencodedintheDrosophilagenome.Itisadigestiveenzymerequiredforthehydrolysisofdietarystarch1,4-Alpha-GlucanBranchingEnzymeisahydrolaseinvolvedindeterminationoflifespan,glycogenbiosynthesisandhypoxia0.940 Amy-dAmy-pFBpp0086136FBpp0086155Alpha-amylase;AmylasedistalisoneofthreeamylasesencodedintheDrosophilagenome.ItisadigestiveenzymerequiredforthehydrolysisofdietarystarchAmylaseproximal,isoformb;Alpha-amylaseB;AmylaseproximalisoneofthreeamylasesencodedintheDrosophilagenome.Itisadigestiveenzymerequiredforthehydrolysisofdietarystarch0.816 Amy-dCG9485FBpp0086136FBpp0071526Alpha-amylase;AmylasedistalisoneofthreeamylasesencodedintheDrosophilagenome.ItisadigestiveenzymerequiredforthehydrolysisofdietarystarchCG9485,isoformB;Amylo-alpha-1,6-glucosidaseactivity;4-alpha-glucanotransferaseactivity.Itisinvolvedinthebiologicalprocessdescribedwith:glycogenbiosyntheticprocess;glycogencatabolicprocess0.920 Amy-dMal-A1FBpp0086136FBpp0087838Alpha-amylase;AmylasedistalisoneofthreeamylasesencodedintheDrosophilagenome.ItisadigestiveenzymerequiredforthehydrolysisofdietarystarchAlpha-glucosidase;MaltaseA1;Cationbinding;catalyticactivity;alpha-1,4-glucosidaseactivity.Itisinvolvedinthebiologicalprocessdescribedwith:carbohydratemetabolicprocess;glucosemetabolicprocess;Belongstotheglycosylhydrolase13family0.813 Amy-dMal-A2FBpp0086136FBpp0087826Alpha-amylase;AmylasedistalisoneofthreeamylasesencodedintheDrosophilagenome.ItisadigestiveenzymerequiredforthehydrolysisofdietarystarchAlpha-glucosidase;MaltaseA2;Cationbinding;catalyticactivity;alpha-1,4-glucosidaseactivity.Itisinvolvedinthebiologicalprocessdescribedwith:carbohydratemetabolicprocess;glucosemetabolicprocess;Belongstotheglycosylhydrolase13family0.808 Amy-dMal-A7FBpp0086136FBpp0087836Alpha-amylase;AmylasedistalisoneofthreeamylasesencodedintheDrosophilagenome.ItisadigestiveenzymerequiredforthehydrolysisofdietarystarchMaltaseA7,isoformA;Cationbinding;alpha-1,4-glucosidaseactivity.Itisinvolvedinthebiologicalprocessdescribedwith:carbohydratemetabolicprocess0.744 Amy-dMal-A8FBpp0086136FBpp0087831Alpha-amylase;AmylasedistalisoneofthreeamylasesencodedintheDrosophilagenome.ItisadigestiveenzymerequiredforthehydrolysisofdietarystarchAlpha-glucosidase;MaltaseA8;Cationbinding;alpha-1,4-glucosidaseactivity.Itisinvolvedinthebiologicalprocessdescribedwith:carbohydratemetabolicprocess0.800 Amy-dtobiFBpp0086136FBpp0084221Alpha-amylase;AmylasedistalisoneofthreeamylasesencodedintheDrosophilagenome.ItisadigestiveenzymerequiredforthehydrolysisofdietarystarchTargetofbraininsulin;Alpha-1,4-glucosidaseactivity.Itisinvolvedinthebiologicalprocessdescribedwith:carbohydratemetabolicprocess;Belongstotheglycosylhydrolase31family0.807 Amy-pAGBEFBpp0086155FBpp0086845Amylaseproximal,isoformb;Alpha-amylaseB;AmylaseproximalisoneofthreeamylasesencodedintheDrosophilagenome.Itisadigestiveenzymerequiredforthehydrolysisofdietarystarch1,4-Alpha-GlucanBranchingEnzymeisahydrolaseinvolvedindeterminationoflifespan,glycogenbiosynthesisandhypoxia0.939 Amy-pAmy-dFBpp0086155FBpp0086136Amylaseproximal,isoformb;Alpha-amylaseB;AmylaseproximalisoneofthreeamylasesencodedintheDrosophilagenome.ItisadigestiveenzymerequiredforthehydrolysisofdietarystarchAlpha-amylase;AmylasedistalisoneofthreeamylasesencodedintheDrosophilagenome.Itisadigestiveenzymerequiredforthehydrolysisofdietarystarch0.816 Amy-pCG9485FBpp0086155FBpp0071526Amylaseproximal,isoformb;Alpha-amylaseB;AmylaseproximalisoneofthreeamylasesencodedintheDrosophilagenome.ItisadigestiveenzymerequiredforthehydrolysisofdietarystarchCG9485,isoformB;Amylo-alpha-1,6-glucosidaseactivity;4-alpha-glucanotransferaseactivity.Itisinvolvedinthebiologicalprocessdescribedwith:glycogenbiosyntheticprocess;glycogencatabolicprocess0.920    page1of5    NetworkStats NetworkStatsanalysisisstillongoing,pleasewait... FunctionalenrichmentsinyournetworkNote:someenrichmentsmaybeexpectedhere(why?) disable highlight  explaincolumns Enrichmentanalysisisstillongoing,pleasewait... Statisticalbackground Fortheaboveenrichmentanalysis,thefollowingstatisticalbackgroundisassumed: WholeGenome AddBackground Update Save/Export Enrichmentanalysisisstillongoing,pleasewait... 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