tobi. Organism. Drosophila melanogaster (Fruit fly). Status. Unreviewed-Annotation score: Annotation score:2 out of 5. The annotation score provides a ...
Anevidencedescribesthesourceofanannotation,e.g.anexperimentthathasbeenpublishedinthescientificliterature,anorthologousprotein,arecordfromanotherdatabase,etc.
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SkipHeader UniProtKBxUniProtKBProteinknowledgebaseUniParcSequencearchiveHelpHelppages,FAQs,UniProtKBmanual,documents,newsarchiveandBiocurationprojects.UniRefSequenceclustersProteomesProteinsetsfromfullysequencedgenomesAnnotationsystemsSystemsusedtoautomaticallyannotateproteinswithhighaccuracy:UniRule(Expertlycuratedrules)ARBA(Systemgeneratedrules)SupportingdataSelectoneoftheoptionsbelowtotargetyoursearch:LiteraturecitationsTaxonomyKeywordsSubcellularlocationsCross-referenceddatabasesHumandiseasesAdvancedSearchxHomeBLASTAlignRetrieve/IDmappingPeptidesearchSPARQLContactHelpYouareusingaversionofbrowserthatmaynotdisplayallthefeaturesofthiswebsite.Pleaseconsiderupgradingyourbrowser.
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WhenbrowsingthroughdifferentUniProtproteins,youcanusethe'basket'tosavethem,sothatyoucanbacktofindoranalysethemlater.
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Selectitem(s)andclickon"Addtobasket"tocreateyourowncollectionhere(400entriesmax)UniProtKB(0)UniRef(0)UniParc(0)AlignBLASTMapIdsDownloadFullViewRemoveClearDisplayHelpvideoEntryPublicationsFeatureviewerFeaturetableAllNoneFunctionNames&TaxonomySubcellularlocationSubcell.locationPathology&BiotechPathol./BiotechPTM/ProcessingExpressionInteractionStructureFamily&DomainsSequenceSimilarproteinsCross-referencesEntryinformationMiscellaneousTopBLAST>tr|Q9VBR6|Q9VBR6_DROMERE74917pOS=DrosophilamelanogasterOX=7227GN=tobiPE=2SV=1
MRFILLSLLLASFCLWEAVHTCASIEQRYKFPNSNVYVRLRRGDKLQYELMKGEKSLQTV
TFDNFDSSANLVETSSGSYQLTDGQSTVEFTLVKSGVVAGTGSEITHVKVSRDQVLQGTQ
PRDCVPLKTGSTHWFSGPEQKQHYWPVERQRHSNYSYLPKELDNFGVGERYWLNGDGVFL
YVESNTPLFIDQNSAAYPDQLCLSAISALPYDPRVTSAKFVYHVAVAKDAKAAHRYAVKT
FLGQPTGYPDERMVMHPVWSTWALYKAEVSDDVVRDFAKQILDNGFNNSQLEIDDDWEDC
YGAMTFRKNKFPDSKTLTDDLKALGFRVTLWIHPFINNNCTAIYDEAKSKGYLVLDHEGS
SDTQWWNSKPKDAAILDFTKTEVQEWFSKRLKRLQDEDGIDSFKFDAGETSWLPSDPVLQ
ASSSMVTPLQAVGDYVRTVAAFGDMVEVRSAQNTQDQPIFVRIVDKDSEWGWNNGLLTLI
SSMLQMNLNGYPFVLPDMIGGNGYYEKPPTKELFLRWLQANVFMPALQFSFVPWNFDDEA
IAISKNFTALHATYTPYIMKLFKRAVDSGEPVNVPLWWIAPTDEVAQSIYDEFLLGEDII
AAPVVVEGATKRDIYLPEGEWQDGNSDQVYTGPTWVMDYAAPLDTLPYFLRVGFTLE
AlignFormatAddtobasketAddedtobasketHistoryEntryversion156(19Jan2022)Sequenceversion1(01May2000)Previousversions|rssCommunitycuration()AddapublicationFeedbackProteinSubmittedname:RE74917pGenetobiOrganismDrosophilamelanogaster(Fruitfly)StatusUnreviewed-Annotationscore:Annotationscore:2outof5
TheannotationscoreprovidesaheuristicmeasureoftheannotationcontentofaUniProtKBentryorproteome.Thisscorecannotbeusedasameasureoftheaccuracyoftheannotationaswecannotdefinethe'correctannotation'foranygivenprotein.
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-Experimentalevidenceattranscriptleveli
Thisindicatesthetypeofevidencethatsupportstheexistenceoftheprotein.Notethatthe'proteinexistence'evidencedoesnotgiveinformationontheaccuracyorcorrectnessofthesequence(s)displayed.
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Selectasectiononthelefttoseecontent.
Thissectionprovidesanyusefulinformationabouttheprotein,mostlybiologicalknowledge.
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Functioni
TheGeneOntology(GO)projectprovidesasetofhierarchicalcontrolledvocabularysplitinto3categories:More...
GO-Molecularfunctionihydrolaseactivity,hydrolyzingO-glycosylcompoundsSource:InterProCompleteGOannotationonQuickGO...GO-BiologicalprocessicarbohydratemetabolicprocessSource:InterProCompleteGOannotationonQuickGO...
UniProtKBKeywordsconstituteacontrolledvocabularywithahierarchicalstructure.KeywordssummarisethecontentofaUniProtKBentryandfacilitatethesearchforproteinsofinterest.More...
KeywordsiMolecularfunctionGlycosidaseUniRuleannotation
InformationwhichhasbeengeneratedbytheUniProtKBautomaticannotationsystem,withoutmanualvalidation.
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AutomaticassertionaccordingtorulesiRuleBase:RU361185Imported
Informationwhichhasbeenimportedfromanotherdatabaseusingautomaticprocedures.
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AutomaticassertioninferredfromdatabaseentriesiEMBL:AAF56462.1,HydrolaseProteinfamily/groupdatabasesCarbohydrate-ActiveenZymesMore...CAZyiGH31,GlycosideHydrolaseFamily31
Thissectionprovidesinformationabouttheproteinandgenename(s)andsynonym(s)andabouttheorganismthatisthesourceoftheproteinsequence.
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Names&Taxonomyi
ThissubsectionoftheNamesandtaxonomysectionprovidesanexhaustivelistofallnamesoftheprotein,fromcommonlyusedtoobsolete,toallowunambiguousidentificationofaprotein.More...
ProteinnamesiSubmittedname:RE74917pImportedAutomaticassertioninferredfromdatabaseentriesiEMBL:ABB36428.1Submittedname:TargetofbraininsulinImportedAutomaticassertioninferredfromdatabaseentriesiEMBL:AAF56462.1(EC:3.2.1.-SearchproteinsinUniProtKBforthisECnumber.SeethedescriptionofthisECnumberinENZYME.SearchreactionsforthisECnumberinRhea.ImportedAutomaticassertioninferredfromdatabaseentriesiEMBL:AAF56462.1)
ThissubsectionoftheNamesandtaxonomysectionindicatesthename(s)ofthegene(s)thatcodefortheproteinsequence(s)describedintheentry.Fourdistincttokensexist:'Name','Synonyms','Orderedlocusnames'and'ORFnames'.More...
GenenamesiName:tobiImportedAutomaticassertioninferredfromdatabaseentriesiEMBL:AAF56462.1FlyBase:FBgn0261575Synonyms:CT33098ImportedAutomaticassertioninferredfromdatabaseentriesiEMBL:AAF56462.1,Dmel\CG11909ImportedAutomaticassertioninferredfromdatabaseentriesiEMBL:AAF56462.1,TobiImportedAutomaticassertioninferredfromdatabaseentriesiEMBL:AAF56462.1ORFNames:CG11909ImportedAutomaticassertioninferredfromdatabaseentriesiEMBL:AAF56462.1FlyBase:FBgn0261575,Dmel_CG11909ImportedAutomaticassertioninferredfromdatabaseentriesiEMBL:AAF56462.1
ThissubsectionoftheNamesandtaxonomysectionprovidesinformationonthename(s)oftheorganismthatisthesourceoftheproteinsequence.More...
OrganismiDrosophilamelanogaster(Fruitfly)ImportedAutomaticassertioninferredfromdatabaseentriesiEMBL:AAF56462.1Proteomes:UP000000803
ThissubsectionoftheNamesandtaxonomysectionshowstheuniqueidentifierassignedbytheNCBItothesourceorganismoftheprotein.Thisisknownasthe'taxonomicidentifier'or'taxid'.More...
Taxonomicidentifieri7227[NCBI]
ThissubsectionoftheNamesandtaxonomysectioncontainsthetaxonomichierarchicalclassificationlineageofthesourceorganism.Itliststhenodesastheyappeartop-downinthetaxonomictree,withthemoregeneralgroupinglistedfirst.More...
Taxonomiclineageicellularorganisms›Eukaryota›Opisthokonta›Metazoa›Eumetazoa›Bilateria›Protostomia›Ecdysozoa›Panarthropoda›Arthropoda›Mandibulata›Pancrustacea›Hexapoda›Insecta›Dicondylia›Pterygota›Neoptera›Endopterygota›Diptera›Brachycera›Muscomorpha›Eremoneura›Cyclorrhapha›Schizophora›Acalyptratae›Ephydroidea›Drosophilidae›Drosophilinae›Drosophilini›Drosophila›Sophophora›melanogastergroup›melanogastersubgroup
ThissubsectionoftheNamesandtaxonomysectionispresentforentriesthatarepartofaproteome,i.e.ofasetofproteinsthoughttobeexpressedbyorganismswhosegenomeshavebeencompletelysequenced.More...
ProteomesiUP000000803
AUniProtproteomecanconsistofseveralcomponents.
Thecomponentnamereferstothegenomiccomponentencodingasetofproteins.More...
Componenti:Chromosome3ROrganism-specificdatabasesDrosophilagenomedatabaseMore...FlyBaseiFBgn0261575,tobiEukaryoticPathogen,VectorandHostDatabaseResourcesMore...VEuPathDBiVectorBase:FBgn0261575
Thissectiondescribespost-translationalmodifications(PTMs)and/orprocessingevents.
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PTM/ProcessingiMoleculeprocessingFeaturekeyPosition(s)DescriptionActionsGraphicalviewLength
Thissubsectionofthe'PTM/Processing'sectiondenotesthepresenceofanN-terminalsignalpeptide.
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Signalpeptidei1 – 18SequenceanalysisAutomaticassertionaccordingtosequenceanalysisiSAM:SignalPAddBLAST18
Thissubsectionofthe'PTM/Processing'sectiondescribestheextentofapolypeptidechaininthematureproteinfollowingprocessingorproteolyticcleavage.
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ChainiPRO_501510009419 – 657SequenceanalysisAutomaticassertionaccordingtosequenceanalysisiSAM:SignalPAddBLAST639
ThissectionprovidesinformationontheexpressionofageneatthemRNAorproteinlevelincellsorintissuesofmulticellularorganisms.
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ExpressioniGeneexpressiondatabasesBgeedataBaseforGeneExpressionEvolutionMore...BgeeiFBgn0261575,Expressedindigestivesystemelementand31othertissues
Thissectionprovidesinformationonthequaternarystructureofaproteinandoninteraction(s)withotherproteinsorproteincomplexes.
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InteractioniProtein-proteininteractiondatabasesSTRING:functionalproteinassociationnetworksMore...STRINGi7227.FBpp0084221
Thissectionprovidesinformationonthetertiaryandsecondarystructureofaprotein.
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Structurei
Thissectionprovidesinformationonsequencesimilaritieswithotherproteinsandthedomain(s)presentinaprotein.
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Family&Domainsi
Thissubsectionofthe'Familyanddomains'sectionprovidesinformationaboutthesequencesimilaritywithotherproteins.
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SequencesimilaritiesiBelongstotheglycosylhydrolase31family.UniRuleannotationAutomaticassertionaccordingtorulesiRuleBase:RU361185ARBAannotationAutomaticassertionaccordingtorulesiARBA:ARBA00007806Keywords-DomainiSignalSequenceanalysisAutomaticassertionaccordingtosequenceanalysisiSAM:SignalPARBAannotationAutomaticassertionaccordingtorulesiARBA:ARBA00022729Phylogenomicdatabasesevolutionarygenealogyofgenes:Non-supervisedOrthologousGroupsMore...eggNOGiKOG1065,EukaryotaEnsemblGeneTreeMore...GeneTreeiENSGT00940000166635TheHOGENOMDatabaseofHomologousGenesfromFullySequencedOrganismsMore...HOGENOMiCLU_008294_0_0_1IdentificationofOrthologsfromCompleteGenomeDataMore...OMAiHADYTPYDatabaseofOrthologousGroupsMore...OrthoDBi238940at2759FamilyanddomaindatabasesGene3DStructuralandFunctionalAnnotationofProteinFamiliesMore...Gene3Di2.60.40.1180,1hitIntegratedresourceofproteinfamilies,domainsandfunctionalsitesMore...InterProiViewproteininInterProIPR000322,Glyco_hydro_31IPR013780,Glyco_hydro_bIPR017853,Glycoside_hydrolase_SFPfamproteindomaindatabaseMore...PfamiViewproteininPfamPF01055,Glyco_hydro_31,1hitSuperfamilydatabaseofstructuralandfunctionalannotationMore...SUPFAMiSSF51445,SSF51445,1hit
Thissectiondisplaysbydefaultthecanonicalproteinsequenceanduponrequestallisoformsdescribedintheentry.Italsoincludesinformationpertinenttothesequence(s),includinglengthandmolecularweight.Theinformationisfiledindifferentsubsections.Thecurrentsubsectionsandtheircontentarelistedbelow:More...
Sequencei
ThissubsectionoftheSequencesectionindicatesifthecanonicalsequencedisplayedbydefaultintheentryiscompleteornot.More...
Sequencestatusi:Complete.Q9VBR6-1[UniParc]FASTAAddtobasketAddedtobasket«Hide1020304050MRFILLSLLLASFCLWEAVHTCASIEQRYKFPNSNVYVRLRRGDKLQYEL60708090100MKGEKSLQTVTFDNFDSSANLVETSSGSYQLTDGQSTVEFTLVKSGVVAG110120130140150TGSEITHVKVSRDQVLQGTQPRDCVPLKTGSTHWFSGPEQKQHYWPVERQ160170180190200RHSNYSYLPKELDNFGVGERYWLNGDGVFLYVESNTPLFIDQNSAAYPDQ210220230240250LCLSAISALPYDPRVTSAKFVYHVAVAKDAKAAHRYAVKTFLGQPTGYPD260270280290300ERMVMHPVWSTWALYKAEVSDDVVRDFAKQILDNGFNNSQLEIDDDWEDC310320330340350YGAMTFRKNKFPDSKTLTDDLKALGFRVTLWIHPFINNNCTAIYDEAKSK360370380390400GYLVLDHEGSSDTQWWNSKPKDAAILDFTKTEVQEWFSKRLKRLQDEDGI410420430440450DSFKFDAGETSWLPSDPVLQASSSMVTPLQAVGDYVRTVAAFGDMVEVRS460470480490500AQNTQDQPIFVRIVDKDSEWGWNNGLLTLISSMLQMNLNGYPFVLPDMIG510520530540550GNGYYEKPPTKELFLRWLQANVFMPALQFSFVPWNFDDEAIAISKNFTAL560570580590600HATYTPYIMKLFKRAVDSGEPVNVPLWWIAPTDEVAQSIYDEFLLGEDII610620630640650AAPVVVEGATKRDIYLPEGEWQDGNSDQVYTGPTWVMDYAAPLDTLPYFLRVGFTLEShow»Length:657Mass(Da):74,598Lastmodified:May1,2000-v1
Thechecksumisaformofredundancycheckthatiscalculated
fromthesequence.Itisusefulfortrackingsequenceupdates.
Itshouldbenotedthatwhile,intheory,twodifferentsequencescould
havethesamechecksumvalue,thelikelihoodthatthiswouldhappen
isextremelylow.
HoweverUniProtKBmaycontainentrieswithidenticalsequencesincase
ofmultiplegenes(paralogs).
Thechecksumiscomputedasthesequence64-bitCyclicRedundancyCheckvalue(CRC64)
usingthegeneratorpolynomial:x64+x4+x3+x+1.
ThealgorithmisdescribedintheISO3309standard.
PressW.H.,FlanneryB.P.,TeukolskyS.A.andVetterlingW.T.
Cyclicredundancyandotherchecksums
NumericalrecipesinC2nded.,pp896-902,CambridgeUniversityPress(1993))
Checksum:i58AF96AEE960296ABLASTProtParamProtScaleComputepI/MWPeptideMassPeptideCutterGOSequencedatabasesSelectthelinkdestinations:EMBLnucleotidesequencedatabaseMore...EMBLiGenBanknucleotidesequencedatabaseMore...GenBankiDNADataBankofJapan;anucleotidesequencedatabaseMore...DDBJiLinksUpdatedAE014297GenomicDNATranslation:AAF56462.1BT023924mRNATranslation:ABB36428.1NCBIReferenceSequencesMore...RefSeqiNP_651391.1,NM_143134.3GenomeannotationdatabasesEnsemblmetazoangenomeannotationprojectMore...EnsemblMetazoaiFBtr0084847;FBpp0084221;FBgn0261575DatabaseofgenesfromNCBIRefSeqgenomesMore...GeneIDi43072KEGG:KyotoEncyclopediaofGenesandGenomesMore...KEGGidme:Dmel_CG11909UCSCgenomebrowserMore...UCSCiCG11909-RA,d.melanogaster
Thissectionprovideslinkstoproteinsthataresimilartotheproteinsequence(s)describedinthisentryatdifferentlevelsofsequenceidentitythresholds(100%,90%and50%)basedontheirmembershipinUniProtReferenceClusters(UniRef).More...
Similarproteinsi90%Identity50%IdentityProteinSimilarproteinsSpeciesScoreLengthSourceQ9VBR6uncharacterizedfamily31glucosidaseKIAA1161DROEL659UniRef90_Q9VBR6uncharacterizedfamily31glucosidaseKIAA1161DRORH657myogenesis-regulatingglycosidaseDROMA657uncharacterizedfamily31glucosidaseKIAA1161DROTK657uncharacterizedfamily31glucosidaseKIAA1161DROFC657+9FullviewProteinSimilarproteinsSpeciesScoreLengthSourceQ9VBR6uncharacterizedfamily31glucosidaseKIAA1161DROEL659UniRef50_Q9VBR6uncharacterizedfamily31glucosidaseKIAA1161DROFC657uncharacterizedfamily31glucosidaseKIAA1161DRORH657UncharacterizedproteinDROYA657myogenesis-regulatingglycosidaseDROMA657+59Fullview
ThissectionisusedtopointtoinformationrelatedtoentriesandfoundindatacollectionsotherthanUniProtKB.
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Cross-referencesiSequencedatabasesSelectthelinkdestinations:EMBLiGenBankiDDBJiLinksUpdatedAE014297GenomicDNATranslation:AAF56462.1BT023924mRNATranslation:ABB36428.1RefSeqiNP_651391.1,NM_143134.33DstructuredatabasesDatabaseofcomparativeproteinstructuremodelsMore...ModBaseiSearch...SWISS-MODELInteractiveWorkspaceMore...SWISS-MODEL-WorkspaceiSubmitanewmodellingproject...Protein-proteininteractiondatabasesSTRINGi7227.FBpp0084221Proteinfamily/groupdatabasesCAZyiGH31,GlycosideHydrolaseFamily31ProtocolsandmaterialsdatabasesTheDNASUplasmidrepositoryMore...DNASUi43072GenomeannotationdatabasesEnsemblMetazoaiFBtr0084847;FBpp0084221;FBgn0261575GeneIDi43072KEGGidme:Dmel_CG11909UCSCiCG11909-RA,d.melanogasterOrganism-specificdatabasesComparativeToxicogenomicsDatabaseMore...CTDi43072FlyBaseiFBgn0261575,tobiVEuPathDBiVectorBase:FBgn0261575PhylogenomicdatabaseseggNOGiKOG1065,EukaryotaGeneTreeiENSGT00940000166635HOGENOMiCLU_008294_0_0_1OMAiHADYTPYOrthoDBi238940at2759MiscellaneousdatabasesBioGRIDORCSdatabaseofCRISPRphenotypescreensMore...BioGRID-ORCSi43072,0hitsin1CRISPRscreenDatabaseofphenotypesfromRNAinterferencescreensinDrosophilaandHomosapiensMore...GenomeRNAii43072GeneexpressiondatabasesBgeeiFBgn0261575,Expressedindigestivesystemelementand31othertissuesFamilyanddomaindatabasesGene3Di2.60.40.1180,1hitInterProiViewproteininInterProIPR000322,Glyco_hydro_31IPR013780,Glyco_hydro_bIPR017853,Glycoside_hydrolase_SFPfamiViewproteininPfamPF01055,Glyco_hydro_31,1hitSUPFAMiSSF51445,SSF51445,1hitMobiDB:adatabaseofproteindisorderandmobilityannotationsMore...MobiDBiSearch...
Thissectionprovidesgeneralinformationontheentry.
More...
Entryinformationi
Thissubsectionofthe'Entryinformation'sectionprovidesamnemonicidentifierforaUniProtKBentry,butitisnotastableidentifier.EachreviewedentryisassignedauniqueentrynameuponintegrationintoUniProtKB/Swiss-Prot.
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EntrynameiQ9VBR6_DROME
Thissubsectionofthe'Entryinformation'sectionprovidesoneormoreaccessionnumber(s).ThesearestableidentifiersandshouldbeusedtociteUniProtKBentries.UponintegrationintoUniProtKB,eachentryisassignedauniqueaccessionnumber,whichiscalled'Primary(citable)accessionnumber'.
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AccessioniQ9VBR6Primary(citable)accessionnumber:Q9VBR6
Thissubsectionofthe'Entryinformation'sectionshowsthedateofintegrationoftheentryintoUniProtKB,thedateofthelastsequenceupdateandthedateofthelastannotationmodification('Lastmodified').Theversionnumberforboththeentryandthecanonicalsequencearealsodisplayed.More...
EntryhistoryiIntegratedintoUniProtKB/TrEMBL:May1,2000Lastsequenceupdate:May1,2000Lastmodified:January19,2022Thisisversion156oftheentryandversion1ofthesequence.Seecompletehistory.
Thissubsectionofthe'Entryinformation'sectionindicateswhethertheentryhasbeenmanuallyannotatedandreviewedbyUniProtKBcuratorsornot,inotherwords,iftheentrybelongstotheSwiss-ProtsectionofUniProtKB(reviewed)ortothecomputer-annotatedTrEMBLsection(unreviewed).
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EntrystatusiUnreviewed(UniProtKB/TrEMBL)
Thissectioncontainsanyrelevantinformationthatdoesn'tfitinanyotherdefinedsections
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MiscellaneousiKeywords-TechnicaltermiReferenceproteomeImportedAutomaticassertioninferredfromdatabaseentriesiProteomes:UP000000803UniProtisanELIXIRcoredataresource
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