Transcriptome Analysis of Long-lived Drosophila ... - Nature

The most differentially expressed gene found was tobi (target of brain insulin). Tobi is a protein that has hydrolase activity and because it ... Skiptomaincontent Thankyouforvisitingnature.com.YouareusingabrowserversionwithlimitedsupportforCSS.Toobtain thebestexperience,werecommendyouuseamoreuptodatebrowser(orturnoffcompatibilitymodein InternetExplorer).Inthemeantime,toensurecontinuedsupport,wearedisplayingthesitewithoutstyles andJavaScript. Advertisement nature scientificreports articles article TranscriptomeAnalysisofLong-livedDrosophilamelanogasterE(z)MutantsShedsLightontheMolecularMechanismsofLongevity DownloadPDF DownloadPDF Subjects AgeingDrosophila AbstractTheE(z)histonemethyltransferaseheterozygousmutationinDrosophilaisknowntoincreaselifespanandstressresistance.However,thelongevitymechanismsofE(z)mutantshavenotbeenrevealed.Usinggenome-widetranscriptomeanalysis,wedemonstratedthatlifespanextension,increaseofresistancetohyperthermia,oxidativestressandendoplasmicreticulumstress,andfecundityenhancementinE(z)heterozygousmutantsareaccompaniedbychangesintheexpressionlevelof239genes(p  2,FDR 1.0foratleast50%samplesofthesmallestgroup).GeneOntology,KEGG,Reactomeenrichmenttestsfortop-50,100,200,500and1000differentiallyexpressedgenes(DEG;p